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Does high b12 mean cancer?
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Does high b12 mean cancer?
Vitamin B12 and folate levels: Low levels of vitamin B12 or folate may signal that a nutritional deficiency is depriving your red blood cells of the ingredients needed to develop normally. Vitamins B12, B6 and folate interact with homocysteine and create other proteins that your body needs. Red blood cells are important because they carry oxygen throughout your body. Advertisement "It was because to me,. 2020 Hyponatremia, the phenomenon of serum sodium level falling below 135 mmol/L, is seen frequently in cancer patients and has been correlated with poor prognosis. A high RDW can indicate some types of cancer,. Cancer, rheumatic disorders, and chronic inflammatory disorders can suppress red cell production. 37 percent to 47 percent for women. A high hematocrit test result above 489% (in women) is considered above normal and may indicate a blood disorder or other medical condition. Uncover the mysteries surrounding elevated vitamin B12 and its potential implications The RDW can differentiate between causes of anemia. An unexplained elevated B12 level should be confirmed later by a second measurement, which. Hemolytic anemia — a type of anemia in which your body destroys red blood cells faster than it produces them, often due to certain blood diseases or autoimmune disorders. Background: Serum vitamin B 12 levels have been proposed as one of the survival prediction factors, although no survival analysis in metastatic cancer patients has been conducted yet. some forms of cancer, coronary artery disease but by insufficient intake of folic acid and vitamins B6 and B12, it is necessary to supplement these elements by correcting the diet. Hypercalcemia is a condition in which the calcium level in the blood becomes too high. Macrocytosis isn't a specific disease, but it may indicate an underlying problem that requires medical evaluation. Numbness, tingling, burning, or weakness in your hands, feet, arms or legs. Given the array of symptoms a vitamin B 12 deficiency can cause, the condition can be overlooked or confused with something else. Some infectious diseases and cancers have been associated with the development of antinuclear antibodies, as have certain drugs. The pancreas is a bodily organ that few people think about. Based on this information, your doctor will refer you to a specialist or order tests to check for kidney cancer or other health problems. According to the National Cancer Institute , the 5-year survival rate when cancer is only in the pancreas is 43 White blood cells only make up about 1% of your blood, but they have an important function. If your blood results reveal a low anion gap, it may mean you have a lower-than-normal level of albumin (hypoalbuminemia). For example, those macrocytic anemia caused by a vitamin B12 deficiency may experience: difficulty walking What does high homocysteine mean? Publication date: 11-07-2024. Vegetarians and vegans are at a high risk of B12 deficiency. The MMACHC gene provides instructions for making a protein that helps convert vitamin B12 (also called cobalamin) into one of two molecules, adenosylcobalamin (AdoCbl) or methylcob. It’s treatable if diagnosed early Try our Symptom Checker Got any other s. We would like to show you a description here but the site won't allow us. High vitamin B12 is a symptom of an underlying illness that causes the amount in your blood to increase. What's new? Several B-complex vitamins have been linked to cancer risk. Low albumin may indicate the following conditions: Kidney issues Liver disease. For example, those macrocytic anemia caused by a vitamin B12 deficiency may experience: difficulty walking What does high homocysteine mean? Publication date: 11-07-2024. What Abnormal Results Mean. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin. On this edition of "Ask Dr Jaffe gives his input on the correlation between high B12 levels in the body and lung cancer. While most people over the age of 50 are encouraged to get regular colonoscopies, it’s important to remember that cancer can strike at any age. There is another test called methylmalonic acid, and it can be measured in either the blood or the urine. While most people over the age of 50 are encouraged to get regular colonoscopies, it’s important to remember that cancer can strike at any age. However, the cancer risk among patients with newly diagnosed high Cbl levels has not been adequately examined. Among these is vitamin B12, an essential B-vitamin that you obtain mostly from the food you eat. A lack of vitamin B12 can cause neurological problems, which affect your nervous system, such as: vision problems pins and needles. The relationship between high levels of vitamin B12 and cancer risk has sparked considerable interest among researchers and healthcare professionals. A high hemoglobin level is often an indicator of disease, including polycythemia vera, cancer, heart disease, lung disease, and kidney or liver disease. But it would caution us to stick with the minimum recommendations so as not to unnecessarily elevate B12 levels beyond what's necessary to prevent deficiency. A high white blood cell (WBC) count can develop due to many conditions, including: Autoimmune diseases and inflammatory conditions that cause the immune system to attack healthy tissues. The strength of the association rose with the increasing B12 level, in particular in cases of metastases. Micro-AbstractElevation of the methylmalonic acid level is a sensitive marker of vitamin B12 deficiency. A physician's order is needed for this test. Interpret your laboratory results now Vitamin B12 and folate are separate tests often used in conjunction to detect deficiencies and to help diagnose the cause of certain anemias, such as pernicious anemia, an autoimmune disease that affects the absorption of B12. What the person above might be confused about is elevated B12 levels cause most of the same symptoms as being deficient in B12. This article is part of an ongoing BULLETIN series. Deficiency should be confirmed by checking the level of a. What Abnormal Results Mean. A high neutrophil count and a low neutrophil count can occur as a result of certain infections, diseases, autoimmune disorders, cancers, medications, or medical treatments. Early symptoms such as stiff joints and fatigue may be due to conditions other than hemochromatosis. For example, a damaged liver may release the vitamin out of storage and into the blood. Macrocytosis isn't a specific disease, but it may indicate an underlying problem that requires medical evaluation. Anemia has many risk factors. This progression is also called metastasis. Jun 25, 2021 · In studies evaluating the association between solid cancer and elevated B12, a single measurement was sufficient to define an elevated B12 level 1,16,17. Autoimmune disease caused by malfunctions of the immune system, such as autoimmune hepatitis, primary biliary cholangitis and primary sclerosing cholangitis. Whilst low blood levels of vitamin B12 indicate deficiency in a test ; elevated blood levels are also often discovered. Study used data from The Health Improvement Network primary. Baseline levels of CRP in purportedly healthy individuals are generally described as being <1-2 μg/ml. B12 is an important nutrient that is popularly used as a nutritional supplement, even by those without a B12 deficiency. No association between liver cancers and elevated B12 level was found after adjustment for chronic liver diseases. Approximately 1 in 3 people with Gilbert's syndrome don't have symptoms. Mean corpuscular hemoglobin or MCH levels refer to the amount of hemoglobin that is present in a red blood cell. And, if you remember, reverse causation is when instead of X leading to Y, maybe Y is instead leading to X. One key lab value that confirms this. Too much calcium in the blood can weaken bones and create kidney stones Other causes of hypercalcemia include cancer, certain other medical conditions and some medicines. Given the array of symptoms a vitamin B 12 deficiency can cause, the condition can be overlooked or confused with something else. Approximately 1 in 3 people with Gilbert's syndrome don't have symptoms. Vitamin B12 plays an important role in energy metabolism. Hemochromatosis can be difficult to diagnose. Here, we critically review current knowledge on B12 in blood plasma, including the presence of the so-called "macro-B12". Approximately 1 in 3 people with Gilbert's syndrome don't have symptoms. Check out this guide to find a cancer treatment center near you, and get started on the road to recove. More specifically, a TIBC test shows the amount of transferrin in your blood. High basophils (basophilia) may be caused by infections, autoimmune diseases, and cancer, while low basophils (basopenia) may be caused by acute infection, hives. All disorders (other than cancer) that affect the liver cause high concentrations of vitamin B12 in plasma. This reflects the potential significance that may have the dosage of vitamin B12 as an early marker of diagnosis of these diseases. Considered alongside the results of other tests, an MCV blood test can help your healthcare provider determine if you have anemia, liver disease or other conditions. Does vitamin B12 give you cancer? We reviewed the latest studies to find the potential link between this common vitamin and various cancers. Optimal Result: 232 - 1245 pg/mL, or 17181 pmol/L. However, in ME/CFS, many people are low in B2 or B6, and some. Anemia or low red blood cell count is a common side effect of cancer and its treatment. Rash or itchy skin that is unexplained. It Isn't entirely understood yet why this happens, and studies continue. So, if your blood test shows high B12 levels, but everything else seems normal, you should keep a couple of things in mind: The standard B12 range of 160 to 950 pg/mL is far from optimal. " Other blood tests may be done to check for other possible causes of low blood counts, such as low levels of vitamin B12 and folate. It is typically induced by certain medications, such as chemotherapy drugs and interferon. Deficiency should be confirmed by checking the level of a substance in the blood called methylmalonic acid. comment dep prenotification from paypal If your blood results reveal a low anion gap, it may mean you have a lower-than-normal level of albumin (hypoalbuminemia). After you go to the bathroom, you may see floating poop. More tests can show if the lymphocyte count is a cause for worry. Iron overload, usually due to hemochromatosis, can be managed. An Underlying Disease. Cancer Matters Perspectives from those who live. Read more for prostate cancer symptoms and treatment. In this study, high serum levels of vitamin B12 were associated with an increased risk of lung cancer. Total and holo-haptocorrin (HC) levels were 26- and 23-fold higher in ALPS patients,. If you have elevated Vitamin B12 levels and you are not taking any. Ferritin is a blood protein that contains iron. If a ferritin test shows that the blood ferritin level is low, it means the body's iron stores are low. tornado warning memphis This test is not as useful in CFS, because it usually comes out normal or high, suggesting that the B12 status is O However, the problem is that the B12 is not being converted into the active forms for use in the biochemistry. This condition is present in a wide range of diseases, and in many cases, it is an independent risk factor for more serious medical conditions. In fact, it’s the second-most common cancer among women in the United States. In this study, high serum levels of vitamin B12 were associated with an increased risk of lung cancer. A high hemoglobin count occurs most commonly when your body requires an increased oxygen-carrying capacity, usually because: You smoke. And maybe stored in the liver that could raise levels Based on your past anemia diagnosis, you most likely would have reactive or secondary thrombocytosis, which is where other conditions cause a high platelet count. The clinical picture says a lot. Supplementing with B vitamins — especially vitamin B6, folic acid, and vitamin B12 — has been linked with an increased risk of lung cancer. A number of hemoglobinopathies are inherited, and certain medications and infections predispose to hemolysis. Find out what causes high B12 levels, how to test them, and when to consult a healthcare provider. A high neutrophil count and a low neutrophil count can occur as a result of certain infections, diseases, autoimmune disorders, cancers, medications, or medical treatments. So your attached report does not suggest blood cancer (attachment removed to protect patient identity). If someone's MCV level is below 80 fl, they will likely develop or have microcytic anemia. az custom knives This progression is also called metastasis. Almost all people who have positive or not the usual type of ANA has a very high feeling for systematic lupus erythematosus (SLE). Healthcare providers use globulin blood tests to measure protein levels in your blood. Here's what to know about the conditions and foods that can make poop float. of multivitamin supplements and cancer was the unplanned outcome, thus the causality of B12 in cancer cannot be judged based on these trials. Falsely elevated serum vitamin B 12 levels mainly composed of increased holoHC were associated with severity (Child-Pugh C and primary liver cancer) and prognosis in chronic viral liver disease. But some studies have an even lower threshold, ranging from 0. Normal ranges for hematocrit levels are: 42 percent to 54 percent of total blood count for men. A vitamin B12 test measures the amount of vitamin B12 in the blood. Although there are a few potential side effects from any dose of B12, it carries little risk of causing serious symptoms or side effects, even at very large doses. High levels may indicate autoimmune disease, infections or cancer. As part of your immune system, they protect you against illnesses.
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damage to parts of the nervous system ( peripheral. Some epilepsy drugs (e, valproic acid, carbamazepine, and phenytoin) can cause vitamin B6 to catalyze faster than normal. An elevated vitamin B12 level can be a nonspecific indicator of several types of solid organ cancer. Primary liver cancer is a life-threatening illness and one of the fastest growing cancer types in the United States. But some studies have an even lower threshold, ranging from 0. It can also result in neurological problems such as tingling in the fingers and toes, the inability to walk normally, and cognitive problems such as memory loss and confusion. If your test shows excessive B12 levels - in the absence of supplementation - this may be a sign of liver disease or cell death (and the breakdown of tissues) that release the B12 back into your blood circulation. To give me peace of mind more than anything, he ordered blood work for several cancer markers. That the body does not have enough vitamins or minerals. Carmel and Eisenberg first recognized this relationship between cancer patients with elevated B12 levels and shorter survival rates than those who had normal or lower levels of this vitamin in 1977, when several other studies confirmed their observations. If you have high serum iron levels and low ferritin, you may want to check for underlying infections, oral contraceptive use, thyroid disorders and consider testing based on history for heavy metals (especially lead) Taking the supplement ip6 is a very very effective iron chelating and anti-cancer supplement. Values of less than 160 pg/mL (118 pmol/L) are a possible sign of a vitamin B12 deficiency. Cancer Matters Perspectives from those who live. Healthy skin and hair - vitamin B12 takes part in the production of cells, thus contributing to healthy skin, hair, and nails. The AMN gene provides instructions for making a protein called amnionless. Bowel cancer is the UK’s fourth most common cancer but it doesn’t have to be this way. koa peat 247 Cancers such as leukemia and Hodgkin's disease A study of elderly Americans in 2007 found that high folate blood levels for patients with normal B12 indicated lower risks of anemia and cognitive impairment. Too much calcium in the blood can weaken bones and create kidney stones Other causes of hypercalcemia include cancer, certain other medical conditions and some medicines. Breast cancer screenings and awareness about the symptoms of breast cancer are increasing, so doctors can d. A disorder that causes your body to produce too many red blood cells, such as polycythemia vera. We compared the cancer-free survival during 60 months between the groups after adjustment for the other elevated-B12-related causes in a survival competing risk model. Low White Blood Count: Learn more about low white blood cell counts, what's "normal," what low WBC could mean, and what you can do about it. Blood loss, decreased red blood cell production, and high rates of red blood cell destruction are linked with certain types of cancer and cancer treatments. "What blood work is common with Sjögren's and how often should it be performed?" by Don Thomas, MD, FACP, FACR. Cancer Matters Perspectives from those who live it every day. A normal MCHC is typically between 32 g/dL to 36 g/dL. It may be caused by abnormalities of RBC production in the bone marrow, altered RBC membrane composition, or an increase in the percentage of reticulocytes, which are larger than mature RBCs. , which included 3702 hospitalized patients in whom high levels of vitamin B12 were found in 12% of cases, whereas a deficiency was only observed in 10% of cases. Regular MVMM-exclusive B12 users presented with 61% higher geometric mean B12 serum levels than non-users (95% CI: 53% - 70%), an association stronger than that. The bottom line. While there is no widely accepted definition of "normal" CRP levels, values above 1 milligram per liter are generally considered to be high. 32 percent to 44 percent for children. If the MCV goes up to an extreme of 125, it may indicate vitamin B12, folate deficiencies, or cold agglutinin disease. Causes Some health conditions, including autoimmune hemolytic anemia, can cause high MCHC results on a blood test. Normal ranges for hematocrit levels are: 42 percent to 54 percent of total blood count for men. A Vitamin B12 level of 2000 is considered high and may indicate an underlying health condition. Another possible cause of elevated vitamin B12 levels is a blood disorder ( QJM, June 2013 ). Some infectious diseases and cancers have been associated with the development of antinuclear antibodies, as have certain drugs. Vitamin B12 deficiency can lead to depression. all fashion channel tv live An average MCV score is between 80 and 95. More specifically, a TIBC test shows the amount of transferrin in your blood. Vitamin B supplementation can have side effects for human health, including cancer risk. Albumin is a protein found in the blood. Globulin Blood Test. Can vitamin B12 cause cancer? At this point in time, there is no solid, conclusive research to show, without a doubt, that a high intake or high levels of vitamin B12 can cause cancer or increase risks of the disease. That's because there are so many conditions that can cause high levels of B2M. We retrospectively included patients having two B[12] measurements with a B[12] initially ≥ 1000 ng/l and a solid cancer diagnosed. This includes blood cancers like leukemia and lymphoma, and solid tumor cancers like colorectal cancer and lung cancer. The Schilling test can determine whether the body absorbs vitamin B12 normally. The authors first ran a nested case-control study, then confirmed their findings using a Mendelian randomization approach based on genetic data from a much larger database including both lung-cancer patients and controls High-risk populations include patients with decreased ileal absorption, decreased IF, inadequate intake, and those taking certain medications known to contribute to vitamin B12 deficiency. The vitamin B12 level is a blood test that measures how much vitamin B12 is in your blood. 5] for a B12 levels between 800 and 1000 pmol/L in the British registry and a SIR of 405–61. Role of Blood Cancers in High B12 Without Supplementation. Iron deficiency can cause anemia. Patients with cancer have been reported to show elevated plasma concentrations of vitamin B12, thus causing uncertainties regarding safety of vitamin B12. kelley blue book value 2013 dodge ram 1500 The Schilling test can determine whether the body absorbs vitamin B12 normally. According to research, around 12 percent of women in the U will be diagnosed with breast can. There is also a condition where a person has too many white blood cells that causes high vitamin B12. Elevated levels of vitamin B-12 have also been linked to prostate cancer. Instead, the patient may have an autoimmune disease such as lupus, rheumatoid arthritis or scleroderma, explains Mayo Clinic. A higher or lower MCHC may indicate different types of anemia. 003 x 10 9 /L (or 3/μL) to 0 A person taking high-dosage supplements of folic acid may be able to correct the anemia and feel better, but the B12 deficiency still exists. A number of hemoglobinopathies are inherited, and certain medications and infections predispose to hemolysis. An unexplained elevated B12 level should be confirmed later by a second measurement, which. Jaundice can turn your skin and whites of the eyes yellow. If you have high serum iron levels and low ferritin, you may want to check for underlying infections, oral contraceptive use, thyroid disorders and consider testing based on history for heavy metals (especially lead) Taking the supplement ip6 is a very very effective iron chelating and anti-cancer supplement. Here's what to know about the link. Enlarged or abnormally shaped bones. Vitamin B12, part of the vitamin B-complex family, is essential for normal nerve function, DNA synthesis, hematopoiesis, fatty acid metabolism, and amino acid synthesis in the mitochondria. One key lab value that confirms this.
Persons with low B12 levels were excluded together with persons with cancer. The study population included patients. If it is high, it indicates that the cells are not making enough adenosyl B12, and thus that there is a functional B12 deficiency. High B12 levels in the blood can be the result of liver disease, kidney failure and blood cancers. etsy fairy lights Learn how artificial lighting and childhood obesity are linked at HowStuffWorks Now. So I'm sure many of you have already read about the role B12 MAY play in lung cancer (seems to be limited to older male smokers). Due to metastasis, stage 4 cancer is usually. Levels below 30 nmol/L (12 ng/mL) are too low, or "deficient," and might weaken your bones and affect your health in other ways. I would like to point out that B12 status is associated with lung cancer. Elevated levels of vitamin B-12 have also been linked to prostate cancer. trailers for rent albuquerque 37 percent to 47 percent for women. One key lab value that confirms this. What Abnormal Results Mean. The female patient had B12 levels within normal range (holotranscobalamin 54 pmol/L) and her diagnosis was confirmed by elevated homocysteine and methylmalonic acid levels. High blood calcium levels are called hypercalcaemia. Healthcare providers typically order ferritin tests for screening and diagnostic purposes. In any case, the physician must do a complete diagnostic workup to track down the reason for. Values of less than 160 pg/mL (118 pmol/L) are a possible sign of a vitamin B12 deficiency. crystal rings etsy A Vitamin B12 level of 2000 is considered high and may indicate an underlying health condition. Participants with a diagnosis of hypertension, dyslipidemia, CVD, and cancer more frequently used vitamin B12-containing supplements than those without these diagnoses. The intricate relationship between folate levels and blood cell. High blood levels of B12 are rare. Codified approach is needed to determine the potential indications of the search for a hypervitaminemia B12 and practice what to do to pass before the discovery of a high serum level of cobalamin. Here's what to expect from each treatment.
On this edition of "Ask Dr Jaffe gives his input on the correlation between high B12 levels in the body and lung cancer. Levels above 125 nmol/L (50 ng/mL) are too high ( 3 ). Ask your doctor to explain what your test results mean. In a person who has established Sjögren's, we use labs to check disease activity, since these may be useful to see how the person does over time, assess how they respond to treatment, and help identify possible disease flares (increased disease activity). They are made in your bone marrow along with other kinds of blood cells. HowStuffWorks checks it out. It can point to liver disease, diabetes, or certain. A new database compiled by the Environmental Working Group shows that the tap water of millions of Americans is unhealthy. This article is part of an ongoing BULLETIN series exploring GE’s innovation, technology, and manufacturing initiatives in India. Cancer of the blood or lymphatic system. Red blood cell counts also can be high in nonalcoholic fatty liver disease. The researchers said that these doses had been long touted by the vitamin industry for increasing energy and improving metabolism. A higher MCV value indicates that the red blood cells are larger than the average size. The strength of the association rose with the increasing B12 level, in particular in cases of metastases. High intakes of folic acid may mask a vitamin B12 deficiency. Experiencing nausea, vomiting or diarrhea. Terran received support at NIH and The Children’s Inn for her rare cancer. We found a higher 1-year cancer risk among the 25,783 (3. We were looking for other possible causes and noticed my B12 was very high (1200 pg/ml) after that test I noticed that anything with higher levels (like 200% of the daily value) of B12 would make my tinnitus worse. The relationship between high levels of vitamin B12 and cancer risk has sparked considerable interest among researchers and healthcare professionals. Experiencing nausea, vomiting or diarrhea. An RDW (red blood cell distribution width) blood test measures how varied your red blood cells are in size and volume. lori lightfoot yelp limo review New research suggests long-term, high-dose supplementation with vitamins B6 and B12 — long touted by the vitamin industry for increasing energy and improving. Moreover, elevated serum levels of vitamin B-12 can be accompanied by signs of deficiency as well, suggesting a functional deficiency from defects in tissue uptake and action of vitamin B-12 at the cellular level. Thrombocytosis is the occurrence of high platelets as a symptom of another condition. Cancers most associated with low hemoglobin include blood cancers, bone cancer, colon cancer, and cervical cancer. Different labs have different cutoff points for normal, low or high results. Here are a few causes that could use a little love while you’ve got. The persistence of elevated B12 was associated with a high incidence of solid cancer at 60 months, in contrast to a transient B12 elevation. The strength of the association rose with the increasing B12 level, in particular in cases of metastases. Learn about this gene and related health conditions. I am a 2-time cancer survivor. Lung or heart disease. Red blood cells are important because they carry oxygen throughout your body. This type of white blood cell is part of the immune system 's frontline defense, and having too many or too few can mean vastly different things. Persons with low B12 levels were excluded together with persons with cancer. In this study, high serum levels of vitamin B12 were associated with an increased risk of lung cancer. But taking high levels of B6 may cause toxicities and even cause nerve damage. Symptoms of high alkaline phosphatase depend on your underlying health condition — such as liver disease or bone disorders. A high white blood cell (WBC) count can develop due to many conditions, including: Autoimmune diseases and inflammatory conditions that cause the immune system to attack healthy tissues. That study had a mean high intake of 246 mcg/day, an amount below the recommended intake, compared to 350-700 mcg/day in other studies. If it is high, it indicates that the cells are not making enough adenosyl B12, and thus that there is a functional B12 deficiency. uc student killed A hematocrit test is a simple blood test that measures the percentage of red blood cells in your blood. Healthy skin and hair - vitamin B12 takes part in the production of cells, thus contributing to healthy skin, hair, and nails. This means that there is enough B12 in the body, but the cells are not able to use it, so they export it back to the blood, and it builds up there, bound to haptocorrin. The study population included patients. This being said, in a thin database cohort study on 757,185 persons, elevated plasma B12 levels were associated with a higher 1. Homocysteine is considered high when it exceeds 16 µmol/L. Macrocytosis is a descriptive term for red blood cell (RBC) size larger than the normal range. Total and holo-haptocorrin (HC) levels were 26- and 23-fold higher in ALPS patients,. People with vitamin B12 deficiency can have neurological symptoms and/or damage without anemia (lack of red blood cells). Total and holo-haptocorrin (HC) levels were 26- and 23-fold higher in ALPS patients,. You are considered asymptomatic if you: Asymptomatic means there are no symptoms. The AMN gene provides instructions for making a prot. A high RDW may be a sign of anemia, liver disease, and even cancer. However, this is unlikely to be. Learn about causes, symptoms, diagnosis and management of anemia. Vitamin B12 or B9 (folate) deficiency anaemia causes the body to produce abnormally large red blood cells. ) Blood and marrow cancers; Damaged bone marrow (due to. Values of less than 160 pg/mL (118 pmol/L) are a possible sign of a vitamin B12 deficiency. You are considered asymptomatic if you: Asymptomatic means there are no symptoms.